Zhouxin Bridge is a major highway and urban road bridge across Beijiang River in Qingyuan City, Guangdong Province. Its main bridge is a double-pylon wide single-plane supporting-system combined girder cable-stayed bridge. Its span layout is 100 m+218 m+100 m. The bridge is 43 m wide with the asymmetric curve shaped pylon and pylon-girder consolidation. The pylon and pier are connected by the ball supports of force measurement and force adjustment. The double-liquid rotary jet grouting technique is adopted in the construction of pile foundation to form the artificial load-holding layer. The carriageway deck slab is the steel-ultrahigh performance concrete composite deck slab. The new drainage structure design is used for the deck drainage. The overall design and key techniques of this bridge are specially introduced.