Based on the research of route selection in the dry-hot valley area of Yuanjiang County, Yuxi City. Comprehensive demonstration and analysis of the geological characteristics of the dry and hot valley area and its influence on the expressway route plan. The study fully analyzes the geological characteristics of the region, and combines the concepts of geological route selection and disaster reduction route selection, consider the impact of engineering geological characteristics and environmental sensitive points in the route corridor. Through the comparison and selection of multiple alternative routes, the principle and method of route selection under the geological conditions of dry-hot valley regions are proposed. The results can provide basis and reference for geological research in similar areas and route selection of high-grade highways under similar geological characteristics.The results can provide basis and reference for geological research in similar areas and route selection of high-grade highways under similar geological characteristics.