The main bridge of Sanguantang bridge is designed as a steel truss bridge with a span arrangement of 160+465+160 m. The main truss of the bridge is the N-shape web member system with vertical and diagonal members. Box sections are used in upper and lower chords. In the plane of the upper chords, the diamond-shaped top lateral bracing are arranged and the bridge deck is the steel orthotropic deck, which is the plate-truss composite structural. The type of the bridge foundation is bored pile. The steel truss is constructed by the cantilever assembly of mid span truss segment and scattered assembly of side span truss segment. The design results of design have great theoretical and practical values for the design of similar type bridge.