Chizhou Yangtze River Highway Bridge is an important control project of highway network "vertical three". This paper researches the key installation technology of pre-pressed steel-rubber combined anti-collision device in Chizhou Yangtze River Highway Bridge, including the installation of self-floating anti-collision device on tower Z5 and the installation of D-type fender on other piers. This paper organizes the order and detailed operation steps of equipment and personnel during installation, and provides reference for the installation of subsequent bridge anti-collision facilities.