SBased on the suspender replacement project of a tied arch bridge, this paper compares and analyzes several suspender replacement construction methods, and selects the appropriate suspender replacement method after fully considering the safety, economy and the particularity that the suspender of this project has an outer steel pipe. In order to ensure the reasonable structural deformation and stress in the whole process of suspender replacement construction, a full bridge finite element model is established to calculate the suspender replacement construction process, and determine the reasonable process of cutting and welding of outer steel pipe, so as to formulate detailed replacement construction steps. During the on-site construction, the internal force of suspender, internal force of steel pipe, stress and deformation of arch rib and tie beam are monitored. The monitoring results show that the direct replacement method is suitable for this project and can provide reference for such projects.