In order to practice and explore the application effect of the "plant - network - river - (lake) - shore" integrated water environment treatment model, taking the south wastewater system area of Wuhu - a pilot city to be protected along the Yangtze River as an example, the "plant - network - river - (lake) - shore" integrated water environment treatment model is systematically sorted out. The practical application of the model in Wuhu Water Environment Treatment Project is introduced emphatically. Finally, the practical achievements and suggestions for implementation of the model are summarized, which can be referred for the similar projects and other cities.