The closed force transferring route of self-anchored suspension bridge is formed through the anchoring connection of the main cable and stiffening girder. The horizontal component force of the main cable is gradually transferred to the stiffening girder of the main span. The vertical component force is balanced mainly by the side span weight. The main girder is a statically indeterminate system under the static force condition, and under the dynamic condition, is usually the full-floating or semi-floating system in order to reach the purpose of seismic mitigation and absorption. This will result in a change in restraint system. This problem is particularly prominent in the single-pylon asymmetric self-anchored suspension bridge. Based on the four-span single-pylon asymmetric self-anchored suspension bridge across Fenhe River in Tongda Street of Taiyuan City, a finite element model of the whole bridge is established to analyze the influence of the different restraint systems on the stress of the whole bridge under the static and dynamic conditions, which provides the basis for the design of the similar structures in the future.