In order to fully understand the seismic response characteristics and seismic performance of high-pier curved bridge in mountainous area, taking the No. 1 Bridge of Daqing Expressway as the engineering background, the calculation model is established by using MIDAS CIVIL software, and the time history analysis is carried out. The effects of seismic incidence angle and friction pendulum support on the displacement of pier top and internal force of pier bottom are studied. The results show that the longitudinal displacement at the top of the pier and the internal force at the bottom of the pier increase first and then decrease with the change of the incident angle of ground motion, and the maximum longitudinal displacement does not appear at the top of the highest pier. The variation of the curved surface radius and the friction coefficient of the friction pendulum bearing have a weak influence on the maximum longitudinal displacement of the pier top. When the radius of the curved surface is fixed and the friction coefficient is 0.01, the longitudinal displacement of the pier top and the internal force of the pier bottom are the maximum.