Abstract:Daxue Road in Yichang City is a municipal road in the China Three Gorges University, and is a part of the important trunk road, Chengdong Avenue to serve an important traffic function. For many years, the social vehicles and campus vehicles in this section of the road have been mixed, and seriously interfere with each other, which will affect the campus environment and cause the great potential safety hazards. Taking the reconstruction of Daxue Road as a typical case, the route of urban road under the complex conditions is studied from the perspective of route location optimization, and the multi-level and multi-angle design ideas are proposed, which can provide reference for the similar projects.