Wusong River Bridge in Suzhou-Jiaxing-Hangzhou Expressway is a variable cross-section continuous beam bridge with a main span of 50 m. Due to the upgrading of the Wusong River channel from the fifth-level channel to the third-level channel, the old bridge does not meet the requirements. After the study of the scheme, it is proposed to demolish the old bridge and build a new bridge. The structural characteristics and construction scheme of a new 132 m-span through steel truss bridge of Wusong River Bridge are introduced including the design details of the number, form, size selection and bridge deck structure of the main truss of the main bridge. In addition, due to the super-saturated traffic volume of Sujiahang Expressway, it is necessary to ensure the traffic during the construction period. The traffic guarantee scheme to build a temporary channel to ensure the normal traffic during the construction of the new Wusong River Bridge is also introduced.