The design scale of Nanjing Dachang Wastewater Treatment Plant (Phase I) is 90 000 m3/d. The effluent quality shall meet the Grade A of Discharge Standard of Pollutants from Municipal Wastewater Treatment Plant (GB 18918—2002). The difficulties in the engineering design of Dachang Wastewater Treatment Plant are introduced and analyzed to determine the process scheme selection and design parameters for the Phase I engineering treatment. The treatment process of modified AAO + magnetic coagulating sedimentation + denitrification deep bed filter + sludge advanced concentration and dehydration is determined. The problem of land shortage is solved through the process selection and cluster layout. The advanced equipment technology is used to ensure the feasibility of reaching the standard of quasi-IV effluent. The certain reference significance is for the design of similar projects.