Based on the dense filling theory, three kinds of skeleton dense iron tailings gravel mixtures with different gradations are designed. The influence of filling degree on the compressive strength and splitting strength of iron tailings gravel mixture is revealed through laboratory tests. In order to further understand the performance of different iron tailings gravel mixtures after stabilized, the heavy compaction test and strength test of iron tailings gravel mixture in three mines around Ma'anshan are carried out, which provide the main technical parameters for the application of iron tailings gravel mixture. The results show that when the filling degree is less than 100%, the filling degree is positively correlated with the compressive strength and splitting strength of mixture. When the filling degree is 98%, the gradation 1 shows the excellent pavement performance. The compressive strength of iron tailings gravel mixture can meet the requirements of different highway grades, and has the excellent freeze-thaw resistance.