As an important part of municipal infrastructure, the location of drainage manhole cover will directly affect the road integrity, structural stability, maintenance safety and driving comfort. The two working conditions of the manhole with the pipeline center located under the curb and under the roadway 0.5 m away from the curb are analyzed. The chamber size of the manhole is optimized. It is proposed that how to carry out the different technological designs of drainage manhole to avoid the location of manhole on roadway under the conditions of limited pipeline layout and when the drainage pipelines are located at the different positions of road section, which can improve the driving comfort and maintenance safety. The research results can provide the reference for the design of the similar projects.