With the development of the fabrication industry in China, the multi-segment prefabricated pier convenient for complex construction in mountainous areas and urban areas has been paid more and more attention due to its characteristics of small segment, light weight. easy transportation and hoisting. Based on the combination of the self-anchored prestressed connection and the traditional grouting sleeve connection. the bearing capacity of multi-segment prefabricated piers can be further improved so as to greatly reduce the section size of the pier column. and make it more suitable for the complex working conditions such as the limited land area of the urban interchange area with auxiliary roads. Combined with the actual application in the new project of Hujia Expressway - Jiaming Viaduct Link, the key control points and key technologies of the whole process from prefabrication to on-site construction of multi-segment prefabricated piers connected by self-anchored prestressed - grouting sleeves are systematically introduced, which provides reference for subsequent similar process construction.