Abstract:The creation of the "Safe Century Quality Project" serves as a key carrier for implementing the five major development concepts of "innovation, coordination, green development, openness and sharing" in the field of highway and waterway construction, as well as for building "Four kinds of transportation", which is of great significance for the transformation and upgrading of the development of transportation infrastructure. In order to promote the construction of the "Safe Century Quality Project" in the Jiangsu Province Expressway Project, the practical experience in the construction and management of Safe Century Quality Project in the expressway projects is discussed from the aspects of design, management quality, safety and information in combination with the creation experience of the safe century quality engineering in the Yancheng - Luoyang National Expressway (Jiangsu Province Suicheng - Shihong) Project, which provides reference for the management of similar expressway projects.