Abstract:To meet the requirements of long-span and high-standard construction of transportation infrastructure, combined with the advantages of steel structure bridges such as strong spanning capacity, high industrialization level and short construction period, and relying on a 72 m+118 m+72 m variable-section continuous steel box beam bridge project in Shenzhen, the key design points and key technologies are studied. By elaborating the project background, engineering overview, and the overall design concept of the three-box single-cell separated cross-section, and focusing on the core issue of local stability control of steel structures, the selection design and verification of rigid ribbed stiffeners are completed, and the local stability reduction coefficient of the compressed zones of the top and bottom plates as well as the influence value of the shear lag effect are quantitatively calculated. Aiming at the complex stress characteristics of the high web plate at the middle support, the layout scheme of longitudinal and transverse ribbed stiffeners is optimized, and its mechanical effect analysis and stability verification are conducted. Additionally, the fatigue failure mechanism of the orthotropic deck is discussed, the influence of plate connection methods on fatigue performance is analyzed, and the multi-model fatigue verification is completed. The research results provide the technical references for the design of similar long-span continuous steel box beam bridges, ensuring the structural safety and engineering applicability.